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Saturday, March 28, 2020

Canine Distemper

Canine Distemper:

1-Introduction.

Canine distemper is a highly contagious, viral and systematic disease of dogs seen worldwide
Clinically canine distemper is characterized by
  1. Diaphasic fever
  2. leukopenia
  3. Respiratory and GI catarrh
  4. Frequently pneumonia
  5. Neurological Complications

 2-Epidemiology.

  • Epidemiology is complicated by the large number of species susceptible to infection
  • Canidae<dog,wolf,raccon>
  • Elephantidae<asian Elephant>
  • Domestic Dogs<including feral population>are considered to be the reservoir species in most, if not all locations.
  • Antigenic drift
  • Canine distemper virus or CDV is a paramyxovirus closely related to the viruses of measles and rinderpest
  • The fragile, enveloped, single-stranded RNA virus is sensitive to lipids such as ether and most disinfectants, including phenols and quaternary ammonium compound
  • some infected dogs shed virus for several months.

3-Pathogenesis:

  • The virus initially replicates in the lymphatic tissue of the respiratory tract.
  • A cell-associated viremia results in infection of all lymphatic tissues which is followed by infection of respiratory, GI and optic nerves
  • The degree of viremia and extent of viral spread to various tissues is moderated by the level of specific humoral immunity in the host during the viremic period.

4-Clinical Findings:

  • Myoclonus<spasmodic jerks>
  • Transient Fever
  • Hyperkeratosis
  • Gliosis is a non-specific reactive change of glial cells in response to damage to the CNS.
  • Mucopurulent Discharge
  • Pustular Dermatitis
    Canine Distemper
  • Encephalomyelitis
  • Neurological signs, muscles twitching, convulsions, head pressing, circling, etc>

5-Diagnosis:

  • Febrile Condition in dogs with multi systematic infection.
  • Characteristic signs do not appear until late. 

6-Differential Diagnosis:

7-Treatment:

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